John Wayne Casserole Recipe
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If you are craving a dish that combines hearty comfort food with bold, zesty flavors, the John Wayne Casserole is your new best friend in the kitchen. This casserole brings together seasoned ground beef, a biscuit crust, and a dreamy blend of sour cream and cheese, all layered with fresh vegetables and just the right kick from jalapeños. It’s the kind of meal that feels like a warm hug after a long day but also stands out with its vibrant, satisfying flavors. Whether you’re serving a family dinner or looking for a crowd-pleasing potluck centerpiece, the John Wayne Casserole delivers every single time.

Ingredients You’ll Need
These ingredients are straightforward yet essential, each adding its unique role to the texture, flavor, and visual appeal of the John Wayne Casserole. From the savory seasoned beef to the fluffy biscuit base and creamy cheese topping, everything works in harmony to create a classic comfort meal loaded with personality.
- 2 pounds ground beef: The hearty, protein-packed foundation that defines the casserole’s savory depth.
- 1 ounce packet taco seasoning: Infuses the beef with a zesty, perfectly spiced punch; you can also use homemade seasoning for a personal twist.
- 16 ounce can large biscuits: Forms the fluffy biscuit crust that’s a golden, soft base to hold all the toppings.
- 1/2 cup sour cream: Adds creaminess and a slight tang that balances the spices beautifully.
- 1/2 cup mayonnaise: Combines with sour cream for a rich, smooth layer that keeps the casserole moist.
- 8 ounces cheddar cheese (shredded and divided): Melts into gooey goodness, both inside and on top, giving each bite a cheesy comfort.
- 1 medium onion (halved and sliced): Offers sweetness and texture, both raw and sautéed in different layers.
- 2 medium tomatoes (sliced): Bring fresh, juicy brightness that contrasts the richness.
- 1 medium red bell pepper (halved and sliced): Adds vibrant color and a mild crunch after sautéing.
- 4 ounces canned sliced jalapeño peppers: The bold, spicy highlight that perfectly elevates the dish without overpowering.
How to Make John Wayne Casserole
Step 1: Prepare Your Oven and Biscuit Crust
Start by preheating your oven to 350 degrees Fahrenheit and positioning an oven rack in the center. Spray a 13×9 glass baking dish with cooking spray to prevent sticking. Arrange the large biscuits in a single layer inside the dish, pressing them together so they form a crust that also climbs halfway up the sides of the pan. Place the dish on a baking sheet to catch any drips and bake for 12 to 15 minutes until the edges are just beginning to turn a light golden brown. This biscuit base is the sturdy, fluffy platform that will carry all the delicious layers in your John Wayne Casserole.
Step 2: Cook the Taco-Seasoned Beef
While the biscuit crust is baking, brown your ground beef in a skillet until fully cooked and drain any excess grease. Add the taco seasoning along with the required amount of water according to the packet instructions (or your homemade seasoning), stirring well to coat the beef evenly. Let it simmer until all the flavors meld and the mixture thickens slightly. Set this spiced, savory beef aside—it’ll be the starring protein component in this welcoming casserole.
Step 3: Mix the Creamy Cheese Layer
In a separate bowl, combine the sour cream, mayonnaise, half of the shredded cheddar cheese, and half of the sliced onions. This mixture provides a luscious, tangy layer that adds moisture and richness to balance the zesty beef and crisp veggies. Give it a good stir so all the ingredients are harmoniously blended.
Step 4: Sauté the Remaining Vegetables
Using the skillet where you cooked the beef (wiped clean), sauté the remaining onions and the sliced red bell pepper until they become slightly tender and fragrant. This step softens the veggies just enough to meld with the other layers, while still preserving some texture and sweetness.
Step 5: Assemble the John Wayne Casserole
Now it’s assembly time, and this is where your casserole comes to life. On top of your baked biscuit crust, layer the cooked taco-seasoned beef first. Next, add the fresh tomato slices followed by the sautéed bell pepper and onion mixture. Spread the canned jalapeño slices evenly over the top for that perfectly balanced bite of heat. Then dollop and spread the creamy sour cream and cheddar mixture over everything before sprinkling the remaining shredded cheddar cheese to crown your masterpiece. Pop this beauty back into the oven and bake uncovered for 30 to 40 minutes until the edges of the biscuit crust are nicely browned and the cheese is melting and bubbly.
How to Serve John Wayne Casserole

Garnishes
For a fresh finishing touch, sprinkle chopped cilantro or fresh green onions over the casserole just before serving. A dollop of extra sour cream or a few slices of ripe avocado on the side will also enhance the creamy, spicy layers perfectly. These simple garnishes elevate the visual appeal and introduce new bursts of flavor that complement the John Wayne Casserole’s bold personality.
Side Dishes
This casserole stands strong on its own but pairing it with a crisp side salad or some fresh-cut veggies provides a welcome contrast in texture and lightness. Cornbread or a warm, soft loaf of bread can also be fantastic for soaking up the cheesy, spicy juices left behind on the plate.
Creative Ways to Present
For a fun twist, try serving individual portions in small ramekins or mini cast-iron skillets for a rustic, personal touch at dinner parties. Alternatively, scoop the casserole over a bed of rice or warm tortillas for a deconstructed taco-night vibe. No matter how you plate it, the John Wayne Casserole always shines with its satisfying layers and bold flavors.
Make Ahead and Storage
Storing Leftovers
Once cooled, cover any leftover John Wayne Casserole tightly with plastic wrap or transfer it to an airtight container. It will keep beautifully in the fridge for up to four days, making it a fantastic choice for next-day lunches or quick dinners.
Freezing
This casserole freezes wonderfully. Wrap it in foil and place it in a freezer-safe container or heavy-duty freezer bag. Label with the date and freeze for up to three months. Freezing is perfect if you want to prepare ahead or save a portion for an easy meal later on.
Reheating
Reheat leftovers in a 350-degree oven until warmed through and the cheese is bubbly again—usually about 20 to 25 minutes. For quicker reheating, microwave portions on medium power in short bursts, stirring or rotating as needed to heat evenly without drying out. You’ll find the casserole tastes just as comforting the second time around.
FAQs
Can I make the John Wayne Casserole vegetarian?
Absolutely! Swap the ground beef for a plant-based alternative or cooked lentils, and use a vegetarian taco seasoning. The layer of veggies and cheese still delivers plenty of flavor and heartiness.
What can I use if I don’t have canned biscuit dough?
If you don’t have biscuit dough on hand, puff pastry or homemade biscuit dough will work well too. Just make sure to adjust the baking time to ensure it’s fully cooked and golden brown.
How spicy is the John Wayne Casserole?
The spice level mainly depends on the amount of jalapeños you add. If you prefer a milder dish, reduce the jalapeños or leave them out altogether. The taco seasoning also contributes spice, so feel free to adjust that to your taste.
Can I prepare parts of this casserole in advance?
Yes! You can brown and season the beef, prepare the sour cream mixture, and sauté the vegetables a day ahead. Just keep them covered in the fridge and assemble the casserole right before baking for the freshest results.
Is this casserole freezer-friendly after baking?
It freezes best before baking. While you can freeze leftovers after baking, the crust might lose some of its original texture. For the best taste, freeze unbaked portions and bake fresh when ready to serve.
Final Thoughts
The John Wayne Casserole is one of those rare dishes that feels nostalgic and exciting at the same time. Its mix of fluffy biscuit base, savory seasoned beef, creamy cheese layers, and fresh veggies creates a symphony of flavors and textures that everyone will love. If you haven’t tried making this comforting casserole yet, consider this your invitation. Trust me, once you dig into your first slice, you’ll want to make the John Wayne Casserole a regular star in your recipe rotation.
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John Wayne Casserole Recipe
- Total Time: 1 hour 15 minutes
- Yield: 8 servings 1x
- Diet: Low Salt
Description
John Wayne Casserole is a hearty, flavorful dish featuring a baked biscuit crust layered with seasoned ground beef, fresh vegetables, a creamy cheese mixture, and jalapeños for a spicy kick. This casserole combines classic Tex-Mex flavors with comforting textures, perfect for family dinners or potlucks.
Ingredients
Meat and Seasoning
- 2 pounds ground beef (browned and drained)
- 1 ounce packet taco seasoning plus water as per packet instructions or homemade taco seasoning
Crust
- 16 ounce can large biscuits
Dairy Mixture
- 1/2 cup sour cream
- 1/2 cup mayonnaise
- 8 ounces cheddar cheese, shredded and divided (4 ounces + 4 ounces)
Vegetables
- 1 medium onion, halved and sliced
- 2 medium tomatoes, sliced
- 1 medium red bell pepper, halved and sliced
- 4 ounces canned sliced jalapeño peppers
Instructions
- Preheat Oven: Preheat your oven to 350°F and place the oven rack in the center. Spray a 13×9 inch glass baking dish with cooking spray to prevent sticking.
- Prepare Biscuit Crust: Place the biscuit dough in a single layer in the prepared pan, pressing the biscuits together and pushing the dough halfway up the sides of the pan. Place the pan on a baking sheet and bake for 12-15 minutes, checking after 12 minutes. The crust should be lightly browned on the edges. Remove from oven and set aside; keep oven on.
- Cook Taco Meat: While the biscuits bake, combine the browned and drained ground beef with the taco seasoning and the water called for by the seasoning packet, then cook according to packet instructions. Once cooked, transfer the meat to a bowl and set aside. Wipe out the pan used for ground beef.
- Mix Dairy Base: In a separate bowl, combine sour cream, mayonnaise, 4 ounces of shredded cheddar cheese, and half of the sliced onions. Stir well until evenly mixed and set aside.
- Sauté Veggies: Using the wiped-out pan, sauté the remaining half of the onions and the sliced red bell peppers over medium heat until they become slightly tender, about 5-7 minutes.
- Assemble Casserole: Layer the casserole starting with the baked biscuit crust, then spread the seasoned taco meat evenly over the crust. Add a layer of tomato slices, followed by the sautéed bell pepper and onion mixture. Scatter the sliced jalapeño peppers evenly on top.
- Add Dairy Mixture and Cheese: Dollop and spread the sour cream mixture over the top layer of vegetables. Finally, sprinkle the remaining 4 ounces of shredded cheddar cheese over everything.
- Bake Final Casserole: Place the assembled casserole in the oven uncovered and bake for 30-40 minutes or until the edges of the biscuit crust are lightly browned and the cheese has fully melted and begun to bubble.
Notes
- Use a baking sheet under the casserole dish when baking the biscuit crust to catch any drips.
- Adjust the amount of jalapeños according to your spice preference.
- For added flavor, consider using homemade taco seasoning with cumin, chili powder, garlic powder, and paprika.
- Let the casserole rest for 5-10 minutes after baking for easier slicing and serving.
- You can substitute the ground beef for ground turkey or chicken for a leaner option.
- Prep Time: 20 minutes
- Cook Time: 55 minutes
- Category: Casserole
- Method: Baking, Sautéing
- Cuisine: Tex-Mex
Nutrition
- Serving Size: 1/8 of casserole (approx. 1.5 cups)
- Calories: 520
- Sugar: 3g
- Sodium: 780mg
- Fat: 35g
- Saturated Fat: 12g
- Unsaturated Fat: 18g
- Trans Fat: 0.5g
- Carbohydrates: 28g
- Fiber: 2g
- Protein: 30g
- Cholesterol: 95mg
Keywords: John Wayne casserole, ground beef casserole, taco casserole, biscuit crust casserole, Tex-Mex casserole, easy dinner casserole